Page 29 - 《华中农业大学学报（自然科学版）》2023年第2期

第 2 期 闵聪聪 等：牛呼吸疾病综合征诊断方法的研究进展 23

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Research progress on diagnostic methods of bovine

respiratory disease complex

MIN Congcong,HOU Qiangqiang,YU Fansong,XIANG Zhijie,
CHEN Yingyu,HU Changmin,GUO Aizhen
College of Veterinary Medicine，Huazhong Agricultural University/
State Key Laboratory of Agricultural Microbiology/
Hubei Hongshan Laboratory，Wuhan 430070，China

Abstract Bovine respiratory disease complex （BRDC） is one of the most important infectious diseas⁃
es that endangers domestic and international cattle industry.The etiological factors include multiple patho⁃
gens such as viruses，bacteria，mycoplasmas，as well as various stressors.Clinical diagnosis is preliminarily
drawn by observing the abnormal signs such as dyspnea and the accuracy of pathogen diagnosis is low.Fur⁃
thermore，because the disease has the characteristics of multi-etiologic mixed infection，the laboratorial diag⁃
nosis is often not specific，which makes it difficult to judge the therapeutic effect and prognosis of the dis⁃
ease.In order to provide reference for early and accurate diagnosis，timely treatment and effective prevention
and control of BRDC，this paper outlined the etiology，epidemiology，hazards，and diagnostic methods of
BRDC，including both conventional clinical and molecular biological diagnostics，as well as new methods
based on host biomarkers such as acute phase proteins，stress-related hormones，and transcriptomic diagno⁃
sis.Further，the practical application，advantages and disadvantages of these methods were briefly described，
and the future direction of diagnostic methods and the problems to be solved were also prospected.
Keywords bovine respiratory disease complex （BRDC）； diagnostic method； pathogens； diagnostic
biomarkers； healthy breeding； comprehensive prevention and control； transcriptome

（责任编辑：边书京）