Page 15 - 《华中农业大学学报（自然科学版）》2022年第4期

第 4 期 杨礼震 等：养猪废水处理工艺对耐药基因迁移影响研究进展 9

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transport of antimicrobials and antimicrobial resistance genes in tenv.2020.140482.

Research progress on transfer effect of antibiotic resistance gene in

swine wastewater treatment process

YANG Lizhen,LIU Tianqi,WANG Lulu,CAO Yunyun,ZHOU Wenbing,XIAO Naidong,CAI Jianbo

College of Resources and Environment，Huazhong Agricultural University/
The Cooperative Innovation Center for Sustainable Pig Production Co-Sponsored
by Province and Ministry，Wuhan 430070，China

Abstract Antibiotic resistance genes（ARGs）in the aquatic environment have become one of the

global health problems，and swine farm is one of the most important sources of ARGs in the environment，
and the discharge of swine wastewater is the main channel for ARGs to enter the environment.At present，
the environmental effect of ARGs from swine wastewater is not clear，the research on ARGs removal by
different swine wastewater treatment processes is still in the initial stage，which needs more in-depth and de‐
tailed study to explore treatment methods that could reduce the abundance of ARGs in swine wastewater.In
this paper，the process of ARGs from production to entry into the environment and the current status of
ARGs pollution in swine farms were reviewed.The distribution and removal efficiency of ARGs in swine
wastewater treatment processes were introduced with emphasis on different wastewater treatment methods
（activated sludge method，anaerobic biological treatment method，physical and chemical method，construct‐
ed wetland method），and it was concluded that physical and chemical method is the most promising way to
reduce ARGs pollution in swine farming environment.The researchers also gained insight into treatments
that might reduce the amount of ARGs in swine wastewater. This paper summarized the occurrence and
transmission of ARGs in the process of swine reproduction.The distribution，migration and transformation
of antibiotic resistance genes in swine wastewater during different treatment processes were analyzed，and
the mechanism of environmental factors affecting its transmission was elucidated.Finally，based on the short‐
comings of the current pig wastewater treatment process in the removal of ARGs，the feasible suggestions of
optimizing the treatment process and strengthening the monitoring of ARGs in each process were put forward.
Keywords resistance genes；antibiotics；gene migration；swine wastewater；swine farms；treatment
technology

（责任编辑：赵琳琳，边书京）