C57BL/6 mice were used to study the antioxidant and health-care functions of Fuzhuan brick tea. Groups including blank control group（N）， high-dose Fuzhuan brick tea gavage group（HF）， CS exposure model group（CS）， CS exposure + low-dose Fuzhuan brick tea gavage group（CSLF）， CS exposure +medium dose Fuzhuan brick tea gavage group（CSMF）， and CS exposure +high-dose Fuzhuan brick tea gavage group（CSHF） were set up. The effects of aqueous extracts from Fuzhuan brick tea on body weight， antioxidant enzymes in serum， and oxidative damage in lung tissues of mice induced by cigarette smoke were analyzed. The results showed that smoke exposure significantly reduced the body weight in mice（P≤0.05） compared with group N and HF. Moreover， the activity of antioxidant enzymes including CAT， GSH-Px， SOD in the serum of mice were significantly decreased（P≤0.05）， with a significant increase in the level of oxidative stress indexes including TNF-α， MDA， ROS， IL-6， IL18 in lung tissues of mice（P≤0.05）. Severe inflammatory reactions occurred in both the alveolar and bronchial areas. The body weight of mice administered with gavage of Fuzhuan brick tea increased. There were no significant differences in the level of CAT， MDA， and IL-18 between the CSLF group and the normal control group（P>0.05）. There were no significant differences in the level of CAT and IL-6 between the CSMF group and the normal control group（P>0.05）. No significant disparities were observed in the level of CAT， MPO， MDA， and IL-6 between the CSHF group and the normal control group（P>0.05）. The sections of lung tissues in mice showed normalization of alveolar septa， significant reduction in microvascular congestion within the alveoli， and decreased inflammatory cells in the CSHF group. It is indicated that cigarette smoke exposure causes severe oxidative damage and inflammatory response in the lung tissues of mice， and the aqueous extracts from Fuzhuan brick tea have a certain effect on repairing cigarette smoke-induced damage of lung tissues in mice.