To further enhance the growth rate and lean meat percentage traits in Huainan pigs through molecular breeding， we performed whole genome methylation sequencing and screened for candidate muscle-regulating genes with differential methylation levels through pathway enrichment analyses using the longissimus dorsi muscle of Huainan boars at 38， 58， and 78 days post coitus （dpc） and at 21 postnatal days. The results showed that the methylation level of mCpG in gene body regions was higher than that in the upstream 2 kb and downstream 2 kb regions of the gene， and the highest methylation levels were observed in introns， 3’UTRs and repeat sequences. During development， the methylation levels in the gene body regions decreased， while those in the upstream 2 kb and downstream 2 kb of the gene regions exhibited a trend of down-up-down. The methylation levels of introns， 3’UTRs and repeat sequences gradually decreased， while the methylation levels of promoter regions exhibited a pattern of down-up-down. Pathway enrichment analyses were conducted， revealing significant differences in CpG methylation of focal adhesion （P=0.000 9， P=0.000 4， P=0.000 1） and CHH methylation of adherents junctions （P=0.013 2， P=0.012 8， P=0.000 5） during the adjacent developmental stages of 38~58 dpc， 58~78 dpc， 78 dpc~21 d of Huainan pigs. Through bioinformatics analyses， ACTN4 and FGFR1 were identified as candidate genes involved in muscle development from these pathways. ACTN4 plays a role in regulating actin binding， and the methylation levels at different developmental stages were found to be 55.75%， 11.18%， 10.18%， and 59.75%. FGFR1 is associated with muscle cell differentiation， and the methylation levels were 0.81%， 0.78%， 7.52%， and 0.44% at different developmental stages. In conclusion， two differentially methylated genes can be selected as candidate genes affecting muscle development to facilitate molecular breeding of Huainan pigs.