The overset mesh model coupled with the VOF model in Fluent software was used to study the two-phase flow to deeply understand the spray coating process of preserved eggs and solve the problems of insufficient theoretical researches on the spray coating of preserved eggs. The liquid film wetting ratio during the coating process under different placement positions of preserved eggs was obtained. The changes of the aspect ratio of the droplets under different pipette parameters were analyzed. The optimal pipette parameters and working pressure for the removal of pendant droplets were selected by the Box- Behnken experiment using the variation index of film thickness as the response value. The results showed that the liquid film wetting ratio of the preserved eggs placed downward after spraying was 1 while the liquid film wetting ratio of the preserved eggs placed with the blunt end down after spraying was only 0.836. The optimal combination of straw parameters screened out was spacing of 14.50 mm， diameter of 12.09 mm， working pressure of 6.97 kPa， and predicted variation index of film thickness of 0.636. The experiments of simulation and the removal of pendant droplets using the air suction device were carried out under the optimal combination of straw parameters. The results showed that the relative error between the simulated value and the predicted value of the variation index of film thickness was 1.73%. The relative error between the observed value and the expected value of the variation index of film thickness was 7.55%， and the relative error between the observed value and the simulated value was 9.12%. Indicating that the coupling model in this study can be used for the simulation test of egg spray coating.