Water is the lifeline and the largest bottleneck for the sustainable development in Xinjiang. Agriculture is the largest water consumer in Xinjiang, accounting for more than 90% of the total socioeconomic water consumption, and the proportion of agricultural water consumption in southern Xinjiang is even higher. The key to water-saving potential in Xinjiang lies in agriculture, and agricultural water saving is the fundamental way to solve the sustainable development of economy and society in Xinjiang. The development of agricultural water-saving in the irrigation areas of Xinjiang was reviewed to improve the agricultural water use efficiency and promote the high-quality development of agriculture in Xinjiang. The current status and existing problems of developing agricultural water-saving were analyzed. The countermeasures and suggestions including vigorously developing water-adapted agriculture, increasing the construction of high-efficient water-saving projects, continuously promoting salt reduction and water saving, strengthening the construction of digitalized irrigation areas, promoting water-saving publicity and training, and improving service system for agricultural water-saving were put forward based on the Central Government’s new positioning and requirements of the country for the development of agriculture in Xinjiang in the new era. It will provide strong support for promoting the sustainable development of modern agriculture and ensuring the national security of grain and cotton production in Xinjiang.