The distribution of potential suitability of tobacco areas in Hubei Province was simulated by using the CLDAS data set of land data assimilation system of China Meteorological Administration from 2008 to 2020 and other environmental factors， and the actual planting sites based on the maximum entropy model （MaxEnt） to comprehensively evaluate the effects of ecological climate factors on the growth and development of tobacco leaves in Hubei Province. The dominant environmental factors that affect its distribution were studied. The results showed that MaxEnt model had a high accuracy in predicting the suitability distribution of tobacco areas with AUC of 0.854. Altitude （650-1 750 m）， soil type （yellow soil）， minimum temperature at the rosette stage （8.9-15.0 ℃）， temperature in the prosperously growing period （16.0-22.9 ℃）， and temperature in the maturing period （18.8-25.6 ℃） were the dominant environmental factors affecting the distribution of tobacco areas in Hubei Province. The highly suitable areas of tobacco are mainly distributed in Enshi， Shiyan， southern Xiangyang and southeastern Yichang， accounting for 18.2% of the total area of Hubei Province. The climate characteristics of 80% of the region are at an altitude of 7 00 to 1 350 m， with an average minimum temperature of 11.2 to 14.5 ℃ in the cluster period， an average temperature of 19.2 to 22.8 ℃ in the peak period， and an average temperature of 22.0 to 25.4 ℃ in the mature period. Among all environmental factors， altitude plays a decisive role， while temperature is an important meteorological factor affecting the growth and development of tobacco. It is indicated that the results are basically consistent with the actual spatial distribution of tobacco growing areas in Hubei Province. It will provide a theoretical reference for the scientific planting and layout of tobacco in Hubei Province.