As an important part of traditional medicine in our country，traditional Chinese medicine has attracted much attention both at home and abroad.However，in recent years，the human health risks caused by the accumulation of heavy metals in traditional Chinese medicine have brought some obstacles to its popularization and application.The health risks caused by heavy metals accumulation depend not only on their total amount，but also on their bio-accessibility and bioavailability.Therefore，it is of great scientific significance and application value to study the bio-accessibility and bioavailability of heavy metals in Chinese traditional medicine.In this paper，the present situation of heavy metal pollution in traditional Chinese medicine was reviewed，and the research progress on the bio-accessibility and bioavailability of heavy metals in traditional Chinese medicine was described.The key factors affecting the bio-accessibility and bioavailability of heavy metals in traditional Chinese medicine and its products were analyzed in depth，starting from the growth environment，self-properties，processing process and testing conditions of original Chinese medicine.We hope to be able to provide theoretical basis and technical support for the prevention and control of heavy metal pollution risks of traditional Chinese medicine.