Nineteen persimmon varieties grown in Wuhan， Hubei Province and thirty-three persimmon varieties grown in Yangling， Shanxi Province， were used to investigate the differences in the content and composition of soluble tannins， the content of insoluble tannins and the free radical scavenging ability of DPPH· among different regions and varieties to study the effects of factors including geography and variety on the composition， the content and the activity of active ingredients in persimmon fruit. The results showed that there were differences in the content and composition of tannins in the persimmon fruits from Wuhan， Hubei Province and Yangling， Shaanxi Province. The monomer components of soluble tannins in persimmon fruits were mainly gallic acid （GA）， epigallocatechin gallate （EGCG）， epicatechin （EC） and catechin （C）. The content of total phenol and the composition of soluble tannins in the pollination content non-astringent （PCNA） grown in Wuhan， Hubei Province were generally higher than those in the PCNA in Yangling， Shaanxi Province. There was no significant difference in the content of insoluble tannins between non-astringent persimmon varieties and astringent persimmon varieties. However， the content of insoluble tannins in astringent varieties and PCNA from Wuhan was generally higher than that from Yangling. The scavenging ability of DPPH· and hydroxyl radical by insoluble tannins in astringent varieties was higher than that in non-astringent varieties. It is indicated that the differences in regions and varieties are important factors affecting the content and composition of tannins in the persimmon fruits.