In order to evaluate the safety of imidacloprid to Procambarus clarkii,indoor exposure test and field residual elimination test were carried out,at the recommended mass concentration of 0.2 mg/L. Samples of P. clarkii,paddy mud and field water were collected separately to study the enrichment and residue elimination of imidacloprid in integrated rice and P. clarkii breeding model. The results showed that the order of imidacloprid accumulation in P. clarkii indoor exposure was gill>muscle>hemolymph>intestine>hepatopancreas. In the field residual test,the order of imidacloprid accumulation in P. clarkii was muscle>intestine>gill tissue>hemolymph>hepatopancreas. At the same time,it was found that 28 days after field application,the imidacloprid residue in the muscle tissue was 20.44 μg/kg, the degradation rate of imidacloprid in paddy field water was 97.54%,and the residual amount in the sediment was 10.94 μg/kg. Therefore,in order to avoid harm to the nontarget biological aquatic product-P. clarkii,it is recommended that the application interval of imidacloprid in rice fields should be properly extend,and in rice fields close to the cultured water,especially in the integrated cultivation mode of rice and shrimp,drugs should be applied cautiously or use other alternative.