Bacterial drug resistance has become the focus of interdisciplinary studies. Nanotechnology can improve the pharmacokinetics of drugs in the application of drug delivery system (drug delivery systems,DDSs) because of its unique physical and chemical properties,which provides a new strategy to deal with the global bacterial resistance. As a drug carrier,the ideal nanoparticles must have a high drug loading,transport the drug to a specific pathological site and/or target cells,do not leak the drug,and release the drug quickly at the site of action. Therefore,people actively seek a variety of “intelligent” nano-drug release systems,which can respond to internal or external stimuli to achieve controllable drug release including pH,redox,temperature,magnetism and light. In this paper,the advances in the field of intelligent antibacterial drug delivery stimulated by pH,temperature,light and enzyme and other intrinsic or exogenous factors are reviewed.