CARMA3 (caspase recruitment domain and membraneassociated guanylate kinaselike domain protein 3) belongs to CARMA family and is a novel scaffold protein.By regulating the activation of NF-κB signaling pathway,CARMA3 controls cell cycle,proliferation and signal transduction,and consequently influences progression of cancers and cellular responses.Here,we comprehensively reviewed NF-κB signaling pathway activation process,including CARMA3mediated NF-κB activation triggered by ligands of GPCRs (G proteincoupled receptors),DNA damage or infection,influence of CARMA3mediated NF-κB activation on VEGF (vascular endothelial growth factor) activity,negative regulation of A20 on CARMA3mediated NF-κB activation,and the link between CARMA3 and cancers,aiming to provide reference for the study of cell cycle progression,proliferation and cellular responses based on NFκB signaling pathway.