To evaluate muscle development and fat deposition of blunt snout bream from Liangzi Lake and Yuni Lake,we detected histomorphological characteristics of the fat and liver,and the variation of fat accumulation by H&E staining,assessed the expression of the genes related to growth rate and lipid metabolism by qPCR.We found that fat accumulation in the mesenteric adipose tissue of blunt snout breams from Yuni Lake was about 1.5fold of that from Liangzi Lake.H&E staining results showed that the diameter of lipid droplet was shorter in the adipose and liver tissue of blunt snout breams from Liangzi Lake than that from Yuni Lake.The expression of LEP in the muscle and adipose tissue of blunt snout breams from Yuni Lake was prominently lower than that from Liangzi Lake (P<0.05),but IGF1 mRNA level was dramatically higher in the muscle of blunt snout breams from Liangzi Lake (P<0.05).The expression of LPL and NPY showed no significant difference in the muscle and adipose tissues of blunt snout breams from Liangzi and Yuni Lake (P＞0.05).From above,we proposed that the capacity of fat accumulation and key genes’ (LEP and IGF1) expression were different in blunt snout breams from two lakes,which may result to the different growth rates of blunt snout breams between two lakes.