Flavonoids,with diverse physiological functions and beneficial effects,are widely distributed and naturally found in different plants.Flavonoids have a common C6-C3-C6 skeletal structure.For better selection and utilization of flavonoids,studying physiological and structure activity relationship of flavonoids is very important.Advances on studies of structure-activity relationship of flavonoids were reviewed from the initial structure-activity relationship studies to a two-dimensional,three-dimensional and holographic quantitative structure-activity relationship studies,which greatly improved the efficiency of studying the activities of flavonoids.