In order to investigate the effects of ginseng polysaccharides on growth index and mRNA expression of antioxidant enzyme in Sparus inacrocephalus,S. inacrocephalus were fed with three different doses of ginseng polysaccharides (0.2,0.4,0.8 g/kg).Growth data were collected and statistically analyzed.Expression levels of superoxide dismutase (SOD),catalase (CAT) and glutathione peroxidase (GSH-PX) mRNAs were detected by real-time PCR at 42 d in the liver.The results showed that dietary ginseng polysaccharides affected the weight gaining rate and hepatosomatic index of S.inacrocephalus significantly.The spleen index,head kidney index and survival ratio had no significant difference with the NC group.The expression of SOD,CAT,GSH-PX mRNA showed an increasing trend.The expression of CAT mRNA in group I was significantly different from the NC group.The expression of SOD,CAT,and GSH-PX mRNA in groupⅡwas significantly increased by 137.28%,57.00% and 117.62%.The expression of SOD mRNA in group Ⅲ was not significantly different changed,and the expression of CAT,GSH-PX mRNA was significantly increased by 38.87%,170.59%.Ginseng polysaccharides can promote the growth and affect non-specific immune function of S.inacrocephalus,with 0.4 g/kg dose of ginseng polysaccharides having the best performance.