A quick method was developed for determining clofentezine residues in oranges by HPLC with dispersive solid phase extraction.The residues of clofentezine in samples was extracted by acetronitrile,cleaned up by PSA and C18 adsorbent.HPLC was performed on a C18 column with UV detection at 268 nm using acetonitrile-water(70∶30,V/V) as mobile phase.The newly developed method showed a good linear relationship at the range of 0.05-5.00 mg/L with good precision and accuracy for clofentezine(R2=0.999 3).The limit of quantification (LOD) of clofentezine in orange pulp and peel was all 0.05 mg/kg.With RSD lower than 8.1% for pulp and peel,the average recoveries were 77.6%-91.6% and 79.3%-105.6% for pulp and peel samples spiked with 0.05-1.00 mg/kg of clofentezine,respectively.