The effects of the dietary complex Chinese herbs on non-specific immune function and disease resistance in yellow catfish (Pelteobagrus fulvidraco R.) were studied.The yellow catfish were divided into 6 groups and were fed with feed supplemented with different ratios of complex Chinese herbs，0 mg/kg（control group,200 mg/kg（groupⅠ）,400 mg/kg （group Ⅱ,600 mg/kg（group Ⅲ）,800 mg/kg（group Ⅳ）and 1 000 mg/kg （group Ⅴ),respectively.Thirty days later,the yellow catfish were blooded,and the leucocytes phagocytic activity,serum lysozyme activity,complement activity and disease resistance were monitored.The results showed that the phagocytic activity of the leucocytes were significantly higher than the control group (t-test,P<0.05).The lysozyme activity of the serum in group Ⅲ,Ⅳ and Ⅴ were significantly higher than the control group (t-test,P<0.05)，but there were no significant differences between group Ⅰ,Ⅱ and the control group (t-test,P>0.05).The complement activity of the serum in group Ⅱ,Ⅲ,Ⅳ and Ⅴ were significantly higher than the control group (t-test,P<0.05),while there were no significant differences between group Ⅰ and control group (t-test,P>0.05).The results showed that the best supplementation ratio of the complex Chinese herbs for the yellow catfish was about 400-800 mg/kg.