This paper used mice as experimental material to establish zinc supplementation and antioxidant experiment.Biological activity of zinc chelating small peptides was investigated.The results showed that,zinc chelating small peptides can markedly improved zinc content in mice liver and serum,also can significantly reduce liver MDA content,improve the activity of T-AOC of mice.Zinc chelating small peptides has a significant effect of zinc supplementation and antioxidant,and is more effective than the same dose of zinc gluconate or zinc sulfate.