The wistar rats were used to study the sub-chronic toxicity of sarafloxacin hydrochloride. The drug was given to 4 groups of animal at levels of 218. 8 mg/kg, 109. 4 mg/kg , 21. 8 mg/kg (equal to 200 mg/kg, 100 mg/kg , 20 mg/kg of sarafloxacin) and 0 by o