首页 > 过刊浏览>2023年第42卷第2期 >9-16. DOI:10.13300/j.cnki.hnlkxb.2023.02.002
PDF HTML阅读 XML下载 导出引用 引用提醒
牛结节性皮肤病流行和防控研究进展
CSTR:
[cstr]
作者:
作者单位:

1.华中农业大学动物医学院/农业微生物资源发掘与利用全国重点实验室,武汉 430070;2.湖北洪山实验室,武汉 430070

作者简介:

袁歆玮，E-mail：yxw9766@webmail.hzau.edu.cn

通讯作者:

郭爱珍，E -mail：aizhen@mail.hzau.edu.cn

中图分类号:

S852.65+3

基金项目:

国家现代农业（肉牛/牦牛）产业技术体系专项（CARS-37）


Research progress on prevalence，prevention and control of lumpy skin disease in cattle
Author:
Affiliation:

1.College of Veterinary Medicine，Huazhong Agricultural University/ State Key Laboratory of Agricultural Microbiology，Wuhan 430070，China;2.Hubei Hongshan Laboratory，Wuhan 430070，China

  • 摘要
    • |
  • 图/表
    • |
  • 访问统计
    • |
  • 参考文献 [41]
    • |
  • 相似文献 [20]
    • | | |
  • 文章评论
    摘要:

    2019年8月首次在我国新疆伊犁暴发牛结节性皮肤病，随后传至全国各地。由于对这一新发病缺少全面认识和防控经验，临床上所用措施常表现出缺少针对性，导致该病的蔓延，给养牛业造成了重大经济损失。为明确该病发生的关键风险因素和防控该病的关键环节，本文从病原学特征、致病机制、临床特征、传播规律、诊断、预防和综合防控措施等方面进行了系统阐述，并针对我国牛结节性皮肤病的有效防控和净化提出了建议。

    Abstract:

    In August 2019，lumpy skin disease （LSD） broke out firstly in Yili，Xinjiang Uygur Autonomous Region，China，and then spread throughout the country.Due to lack of comprehensive knowledge and experience in prevention and control of LSD，clinically，they are often lack of targeted measures，leading to the spread of the disease and causing significant economic losses to the cattle industry.Therefore，in order to identify the key risk factors and the key links of prevention and control of LSD，this paper comprehensively reviewed the etiological characteristics，pathogenic mechanism，clinical characteristics，transmission rules，diagnosis，prevention and control measures，and put forward suggestions for the effective prevention and control and elimination of LSD in China.

    表 1 LSDV与其他痘病毒的致病相关基因的同源基因特征Table 1 Comparison between LSDV homologues and virulence related genes in other pox viruses
    表 2 WOAH推荐用于牛结节性皮肤病的诊断检测方法及其适用目的Table 2 Diagnostic tests of lumpy skin disease in cattle and their diagnostic purposes recommended by WOAH
    图1 全球LSD疫情在非洲、欧洲和亚洲的时间分布图Fig.1 Temporal distribution of global LSD outbreaks in Africa，Europe and Asia
    图2 我国2020-2021年LSD发病情况Fig.2 Number of LSD cases outbreaks in cattle in China from 2020-2021
    参考文献
    [1] WOAH.Manual of diagnostic tests and vaccines for terrestrial animals 2021-lumpy skin diseases (version adopted in May 2021) [M].Paris:WOAH Terrestrial Manual,2021.
    [2] 农业农村部.农业农村部关于印发《牛结节性皮肤病防治技术规范》的通知.农牧发[2020]30号[Z].The Ministry of Agriculture and Rural Affairs,PRC.Notice of the ministry of agriculture and rural affairs on the technical specification for prevention and treatment of lumpy skin disease in cattle,2020,No.30[Z] (in Chinese).
    [3] 杨治聪,侯巍,莫茜,等.牛结节性皮肤病国际国内流行情况[J].山东畜牧兽医,2021,42(10):66-71,74.YANG Z C,HOU W,MO Q,et al.International and domestic epidemic situation of bovine nodular dermatosis[J].Shandong journal of animal science and veterinary medicine,2021,42(10):66-71,74(in Chinese).
    [4] 刘平,李金明,陈荣贵,等.我国首例牛结节性皮肤病的紧急流行病学调查[J].中国动物检疫,2020,37(1):1-5.LIU P,LI J M,CHEN R G,et al.The first outbreak investigation of lumpy skin disease in China[J].China animal health inspection,2020,37(1):1-5(in Chinese with English abstract).
    [5] FAO.Emergence of lumpy skin disease in the eastern mediterranean basin countries[R].Rome:Empres watch,2013.
    [6] ABUTARBUSH S M,ABABNEH M M,ALZOUBI I G,et al.Lumpy skin disease in Jordan:disease emergence,clinical signs,complications and preliminary-associated economic losses[J].Transboundary and emerging diseases,2015,62(5):549-554.
    [7] AL-SALIHI K A,HASSAN I Q.Lumpy skin disease in Iraq:study of the disease emergence[J].Transboundary and emerging diseases,2015,62(5):457-462.
    [8] YOUSEFI S P,MARDANI K,DALIR-NAGHADEH B,et al.Epidemiological study of lumpy skin disease outbreaks in north-western Iran[J].Transboundary and emerging diseases,2017,64(6):1782-1789.
    [9] BEARD P M.Lumpy skin disease:a direct threat to Europe[J].The veterinary record,2016,178(22):557-558.
    [10] SPRYGIN A,ARTYUCHOVA E,BABIN Y,et al.Epidemiological characterization of lumpy skin disease outbreaks in Russia in 2016[J].Transboundary and emerging diseases,2018,65(6):1514-1521.
    [11] 景志忠,贾怀杰,陈国华,等.牛结节性皮肤病的流行现状与传播特征及其我国的防控策略[J].中国兽医科学,2019,49(10):1297-1304.JING Z Z,JIA H J,CHEN G H,et al.Prevalence status and transmission characteristics of bovine lumpy skin disease and prevention and control strategy in China[J].Chinese veterinary science,2019,49(10):1297-1304(in Chinese with English abstract).
    [12] European Food Safety Authority (E F S A).Lumpy skin disease epidemiological report IV:data collection and analysis[J/OL].EFSA journal,2020,18(2):e06010[2022-06-29].http://doi.org/10.2903/j.efsa.2020.6010.
    [13] KAHANA-SUTIN E,KLEMENT E,LENSKY I,et al.High relative abundance of the stable fly Stomoxys calcitrans is associated with lumpy skin disease outbreaks in Israeli dairy farms[J].Medical and veterinary entomology,2017,31(2):150-160.
    [14] BADHY S C,CHOWDHURY M G A,SETTYPALLI T B K,et al.Molecular characterization of lumpy skin disease virus (LSDV) emerged in Bangladesh reveals unique genetic features compared to contemporary field strains[J/OL].BMC veterinary research,2021,17(1):61[2022-06-29].https:// doi.org/10.1186/s12917-021-02751-x.
    [15] SUDHAKAR S B,MISHRA N,KALAIYARASU S,et al.Genetic and phylogenetic analysis of lumpy skin disease viruses (LSDV) isolated from the first and subsequent field outbreaks in India during 2019 reveals close proximity with unique signatures of historical Kenyan NI-2490/Kenya/KSGP-like field strains[J].Transboundary and emerging diseases,2022,69(4):e451-e462.
    [16] TRAN H T T,TRUONG A D,DANG A K,et al.Lumpy skin disease outbreaks in Vietnam,2020[J].Transboundary and emerging diseases,2021,68(3):977-980.
    [17] ARJKUMPA O,SUWANNABOON M,BOONRAWD M,et al.First emergence of lumpy skin disease in cattle in Thailand,2021[J].Transboundary and emerging diseases,2021,68(6):3002-3004.
    [18] 张敏敏,孙亚杰,刘文兴,等.我国首次牛结节性皮肤病病毒的分离鉴定[J].中国预防兽医学报,2020,42(10):1058-1061.ZHANG M M,SUN Y J,LIU W X,et al.Isolation and identification of lumpy skin disease virus from the first outbreak in China[J].Chinese journal of preventive veterinary medicine,2020,42(10):1058-1061(in Chinese with English abstract).
    [19] MOSS B.Poxvirus entry and membrane fusion[J].Virology,2006,344(1):48-54.
    [20] SPRYGIN A,BABIN Y,PESTOVA Y,et al.Analysis and insights into recombination signals in lumpy skin disease virus recovered in the field[J/OL].PLoS One,2018,13(12):e0207480[2022-06-29].http://doi.org/10.1371/journal.pone.0207480.
    [21] SPRYGIN A,PESTOVA Y,BJADOVSKAYA O,et al.Evidence of recombination of vaccine strains of lumpy skin disease virus with field strains,causing disease[J/OL].PLoS One,2020,15(5):e0232584[2022-06-29].http://doi.org/10.1371/journal.pone.0232584.
    [22] MA J,YUAN Y,SHAO J,et al.Genomic characterization of lumpy skin disease virus in southern China[J/OL].Transboundary and emerging diseases,2021,10.1111/tbed.14432[2022-06-29].http://doi.org/10.1111/tbed.14432.
    [23] HUNTER P,WALLACE D.Lumpy skin disease in southern Africa:a review of the disease and aspects of control[J].Journal of the South African veterinary association,2001,72(2):68-71.
    [24] SANZ-BERNARDO B,HAGA ISMAR R,WIJESIRIWARDANA N,et al.Quantifying and modeling the acquisition and retention of lumpy skin disease virus by hematophagus insects reveals clinically but not subclinically affected cattle are promoters of viral transmission and key targets for control of disease outbreaks[J/OL].Journal of virology,2021,95(9):e02239- e02220 [2022-06-29].http://doi.org/10.1128/JVI.02239-20.
    [25] MULATU E,FEYISA A.Review:lumpy skin disease[J/OL].Journal of veterinary science and technology,2018,9:3[2022-06-29].http://doi.org/10.4172/2157-7579.1000535.
    [26] ANNANDALE C H,HOLM D E,EBERSOHN K,et al.Seminal transmission of lumpy skin disease virus in heifers[J].Transboundary and emerging diseases,2014,61(5):443-448.
    [27] LUBINGA J C,TUPPURAINEN E S M,STOLTSZ W H,et al.Detection of lumpy skin disease virus in saliva of ticks fed on lumpy skin disease virus-infected cattle[J].Experimental and applied acarology,2013,61(1):129-138.
    [28] TUPPURAINEN E S M,VENTER E H,COETZER J A W,et al.Lumpy skin disease:attempted propagation in tick cell lines and presence of viral DNA in field ticks collected from naturally-infected cattle[J].Ticks and tick-borne diseases,2015,6(2):134-140.
    [29] HAIG D M.Poxvirus interference with the host cytokine response[J].Veterinary immunology and immunopathology,1998,63(1/2):149-156.
    [30] ZHANG K,LIU Y,SHANG Y,et al.Major virulence factors of orf virus and their mechanism for immune evasion[J/OL].Austin journal of infectious diseases,2014,1(1):5[2022-06-29].http://doi.org/ajid-v1-id1005.
    [31] NICHOLS D B,DE MARTINI W,COTTRELL J.Poxviruses utilize multiple strategies to inhibit apoptosis[J/OL].Viruses,2017,9(8):215[2022-06-29].http://doi.org/10.3390/v9080215.
    [32] BIDGOOD S R,MERCER J.Cloak and dagger:alternative immune evasion and modulation strategies of poxviruses[J].Viruses,2015,7(8):4800-4825.
    [33] BERTIN J,ARMSTRONG R C,OTTILIE S,et al.Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis[J].PNAS,1997,94(4):1172-1176.
    [34] BOSHRA H,TRUONG T,NFON C,et al.A lumpy skin disease virus deficient of an IL-10 gene homologue provides protective immunity against virulent capripoxvirus challenge in sheep and goats[J].Antiviral research,2015,123:39-49.
    [35] KARA P D,MATHER A S,PRETORIUS A,et al.Characterisation of putative immunomodulatory gene knockouts of lumpy skin disease virus in cattle towards an improved vaccine[J].Vaccine,2018,36(31):4708-4715.
    [36] TUPPURAINEN E,DIETZE K,WOLFF J,et al.Review:vaccines and vaccination against lumpy skin disease[J/OL].Vaccines,2021,9(10):1136[2022-06-29].https://doi.org/10.3390/vaccines9101136.
    [37] BEN-GERA J,KLEMENT E,KHINICH E,et al.Comparison of the efficacy of Neethling lumpy skin disease virus and x10RM65 sheep-pox live attenuated vaccines for the prevention of lumpy skin disease:the results of a randomized controlled field study[J].Vaccine,2015,33(38):4837-4842.
    [38] KRE?I? N,?IMI? I,BEDEKOVI? T,et al.Evaluation of serological tests for detection of antibodies against lumpy skin disease virus[J/OL].Journal of clinical microbiology,2020,58(9):e00348-e00320 [2022-06-29].http://doi.org/10.1128/JCM.00348-20.
    [39] MILOVANOVI? M,DIETZE K,MILI?EVI? V,et al.Humoral immune response to repeated lumpy skin disease virus vaccination and performance of serological tests[J/OL].BMC veterinary research,2019,15(1):80[2022-06-29].http://doi.org/10.1186/s12917-019-1831-y.
    [40] AGIANNIOTAKI E I,SHAWN B,PANAGIOTIS-DIMITRIOS K,et al.Colostrum transfer of neutralizing antibodies against lumpy skin disease virus from vaccinated cows to their calves[J].Transboundary and emerging diseases,2018,65(6):2043-2048.
    [41] CHIHOTA C M,RENNIE L F,KITCHING R P,et al.Attempted mechanical transmission of lumpy skin disease virus by biting insects[J].Medical and veterinary entomology,2003,17(3):294-300.
    引证文献
    网友评论
    网友评论
    分享到微博
    发 布
引用本文

袁歆玮,王宇,阿地力·阿不来提,陈颖钰,李家奎,郭爱珍.牛结节性皮肤病流行和防控研究进展[J].华中农业大学学报,2023,42(2):9-16

复制
分享
文章指标
  • 点击次数:1554
  • 下载次数: 3708
  • HTML阅读次数: 442
  • 引用次数: 0
历史
  • 收稿日期:2022-06-29
  • 在线发布日期: 2023-03-31
文章二维码

联系我们

电话： 027-87287437，027-87287364
邮政编码： 430070
E-mail：hnlkxb@mail.hzau.edu.cn
地址： 武汉市洪山区狮子山街1号

期刊订阅 Email Alert 国际标准刊号：ISSN 1000-2421 国外邮发代号：BM 3816 国内刊号：CN 42-1181/S 国内发行代号：38-120

华中农业大学学报（自然科学版） ® 2025 版权所有   技术支持：北京勤云科技发展有限公司