During the process of coevolution between insects and plants，insects successfully localize host plants to determine their feeding habits and niche.Nevertheless，the molecular mechanism of host localizing of insects remains largely unknown.The true fruit flies （Diptera：Tephritidae） are important pests infesting fruits and vegetables all over the world.Research shows that vision and olfaction of tephritid fruit flies play critical roles in host location.Currently，the trapping device which simulates color and odor can trap and kill the tephritid fly effectively，but the effect of trapping and killing is uneven.This paper reviews the progress of the host location behavior through vision and olfaction by fruit flies as well as related molecular basis，and the application effects.Finally，the future perspective is discussed in order to pave the way for developing eco-friendly control measures against fruit fly pests.