茯砖茶水提物对香烟烟雾致小鼠肺损伤的修复作用
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作者:
作者单位:

1.怀化职业技术学院农学园艺学院,怀化 418099;2.湖南农业大学园艺学院/茶学教育部重点实验室/国家植物功能成分利用工程技术研究中心,长沙 410128

作者简介:

仇云龙,E-mail:462870553@qq.com

通讯作者:

禹利君,E-mail:yulijun_tea@qq.com

中图分类号:

TS272.5;R151

基金项目:

湖南省自然科学基金项目(2024JJ7389);湖南省教育厅科学研究项目(23C0927);怀化职业技术学院“揭榜挂帅”项目(JBZD202402)


Effects of extracts from Fuzhuan brick tea on repairing damage in lung tissues of mice induced by cigarette smoke
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Affiliation:

1.College of Agriculture and Horticulture,Huaihua Vocational and Technical College, Huaihua 418099,China;2.College of Horticulture/Ministry of Education Key Laboratory of Tea Science/National Research Center of Engineering and Technology for Utilization of Botanical Functional Ingredients,Hunan Agricultural University,Changsha 410128,China

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    摘要:

    为探究茯砖茶的抗氧化保健功能,以C57BL/6小鼠为实验对象,设置空白对照组(N)、高剂量茯砖茶灌胃组(HF)、CS暴露模型组(CS)、CS暴露+低剂量茯砖茶灌胃组(CSLF)、CS暴露+中剂量茯砖茶灌胃组(CSMF)、CS暴露+高剂量茯砖茶灌胃组(CSHF),分析茯砖茶水提物对香烟烟雾致小鼠体质量、血清抗氧化酶以及肺组织氧化损伤的影响。结果显示:与N组和HF组比较,烟雾暴露导致小鼠体质量显著降低(P≤0.05),此外,小鼠血清抗氧化酶(CAT、GSH-PX、SOD)活性显著降低(P≤0.05),肺组织氧化应激指标(TNF-α、MDA、ROS、IL-6、IL-18)显著增加(P≤0.05),肺泡及支气管均出现较严重的炎症反应。灌胃茯砖茶水提物后,小鼠体质量上升,CSLF组CAT、MDA、IL-18与正常对照组无显著性差异(P>0.05);CSMF组CAT、IL-6与正常对照组无显著性差异(P>0.05);CSHF组CAT、MPO、MDA、IL-6与正常对照组无显著性差异(P>0.05),小鼠肺组织切片显示出肺泡间隔正常化,肺泡内微血管充血大量减少,炎性细胞减少。研究表明,香烟烟雾暴露对小鼠肺部造成较严重的氧化损伤和炎症反应,茯砖茶水提物对香烟烟雾致小鼠肺损伤具有一定的修复作用。

    Abstract:

    C57BL/6 mice were used to study the antioxidant and health-care functions of Fuzhuan brick tea. Groups including blank control group(N), high-dose Fuzhuan brick tea gavage group(HF), CS exposure model group(CS), CS exposure + low-dose Fuzhuan brick tea gavage group(CSLF), CS exposure +medium dose Fuzhuan brick tea gavage group(CSMF), and CS exposure +high-dose Fuzhuan brick tea gavage group(CSHF) were set up. The effects of aqueous extracts from Fuzhuan brick tea on body weight, antioxidant enzymes in serum, and oxidative damage in lung tissues of mice induced by cigarette smoke were analyzed. The results showed that smoke exposure significantly reduced the body weight in mice(P≤0.05) compared with group N and HF. Moreover, the activity of antioxidant enzymes including CAT, GSH-Px, SOD in the serum of mice were significantly decreased(P≤0.05), with a significant increase in the level of oxidative stress indexes including TNF-α, MDA, ROS, IL-6, IL18 in lung tissues of mice(P≤0.05). Severe inflammatory reactions occurred in both the alveolar and bronchial areas. The body weight of mice administered with gavage of Fuzhuan brick tea increased. There were no significant differences in the level of CAT, MDA, and IL-18 between the CSLF group and the normal control group(P>0.05). There were no significant differences in the level of CAT and IL-6 between the CSMF group and the normal control group(P>0.05). No significant disparities were observed in the level of CAT, MPO, MDA, and IL-6 between the CSHF group and the normal control group(P>0.05). The sections of lung tissues in mice showed normalization of alveolar septa, significant reduction in microvascular congestion within the alveoli, and decreased inflammatory cells in the CSHF group. It is indicated that cigarette smoke exposure causes severe oxidative damage and inflammatory response in the lung tissues of mice, and the aqueous extracts from Fuzhuan brick tea have a certain effect on repairing cigarette smoke-induced damage of lung tissues in mice.

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仇云龙,禹利君.茯砖茶水提物对香烟烟雾致小鼠肺损伤的修复作用[J].华中农业大学学报,2025,44(6):87-94

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  • 收稿日期:2025-07-31
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  • 在线发布日期: 2025-12-16
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