首页 > 过刊浏览>2025年第44卷第1期 >156-167. DOI:10.13300/j.cnki.hnlkxb.2025.01.017
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病原真菌CFEM蛋白功能及分子机制研究进展
作者:
作者单位:

兰州理工大学生命科学与工程学院，兰州 730050

通讯作者:

王艳玲，E-mail： wangyanling2003359@126.com

中图分类号:

S435

基金项目:

国家自然科学基金地区科学基金项目（31760494）；兰州市青年科技人才创新项目（2023-QN-64）


Function and molecular mechanism of the CFEM protein in plant pathogenic fungi
Author:
Affiliation:

College of Life Science and Technology， Lanzhou University of Technology， Lanzhou 730050， China

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    摘要:

    CFEM （common in fungi extracellular membrane）蛋白是仅存在于真菌的一种细胞外膜蛋白，在真菌中往往起到效应子的作用。本文阐述了不同病原真菌CFEM蛋白的结构、起源、进化及其作用和分子机制，强调了致病性真菌中CFEM蛋白在获取铁元素、维护真菌细胞壁完整性、影响真菌生长发育、侵染结构形成及引发宿主免疫反应等方面的重要作用。同时对扩展青霉的CFEM蛋白进行生物信息学分析，并针对未来CFEM蛋白在侵染致病中的作用及分子机制等研究进行讨论和展望。旨在进一步解析CFEM蛋白在侵染致病中的作用和分子机理，为防控植物病原真菌病害提供理论基础和参考。

    Abstract:

    The CFEM （common in fungi extracellular membrane） protein is an extracellular membrane protein that is unique to fungi and often founctions as an effector in various fungal species. This article elucidates the structure， origin， evolution， function， and molecular mechanisms of CFEM proteins across different pathogenic fungi. It highlights the critical roles of CFEM proteins in pathogenic fungi， including iron acquisition， maintenance of fungal cell wall integrity， influence on fungal growth and development， facilitation of infection structure formation， and elicitation of host immune responses. Additionally， a bioinformatic analysis of CFEM proteins in Penicillium expansum is presented. Future research directions on the roles and molecular mechanisms of CFEM proteins in fungal pathogenicity are also discussed. The aim is to enhance our understanding of the function and molecular mechanisms of CFEM proteins in fungal infection and pathogenesis， providing a theoretical foundation and reference for controlling plant fungal diseases.

    图1 CFEM蛋白中8个保守的半胱氨酸［11］Fig.1 There are eight highly conserved cysteine residues in the CFEM domain
    图2 P. expansum 中CFEM的结构域Fig.2 The structure domain of CFEMs in P. expansum
    图4 P. expansum中CFEM蛋白的三维结构Fig.4 Three-dimensional structure of the CFEM proteins in P. expansum
    图3 Candida albicans 中Csa2的三级结构［27］Fig.3 The structure of Csa2 in Candida albicans
    图5 不同物种的CFEM系统发育树Fig.5 The phylogenetic tree of CFEM systems across different species
    图6 病原真菌CFEM的功能及分子机制［13，18，32，56，59］Fig.6 Schematic of the function and mechanism of CFEM in pathogenic fungi
    表 1 在扩展青霉中鉴定的9个CFEM蛋白Table 1 The 9 CFEM proteins identified in Penicillium expansum
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王艳玲,郭勇,高洁.病原真菌CFEM蛋白功能及分子机制研究进展[J].华中农业大学学报,2025,44(1):156-167

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