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miRNA在乳腺癌中的研究进展
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作者:
作者单位:

武汉理工大学化学化工与生命科学学院/神经退行性疾病纳米医药湖北省重点实验室，武汉 430070

作者简介:

雷志鑫，E-mail：leizhixin@whut.edu.cn

通讯作者:

孙涛垒，E-mail：suntl@whut.edu.cn

中图分类号:

R - 05;R282.71;R737.9

基金项目:

国家自然科学基金项目（32202857）


Research progress of miRNA in breast cancer
Author:
Affiliation:

School of Chemistry，Chemical Engineering and Life Science/Hubei Provincial Key Laboratory of Nanomedicine for Neurodegenerative Diseases，Wuhan University of Technology，Wuhan 430070，China

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    摘要:

    乳腺癌是全球3种最常见的癌症之一，对人类健康构成严重威胁。MicroRNA（miRNA）作为一种基因调控的小分子，可以介导细胞靶基因调控乳腺癌发生和发展进程。本文根据miRNA的来源进行分类并综述了当前已知内源性与外源性miRNA（植物元）的功能特性，并探讨这些miRNA在乳腺癌调控中的作用机制。同时，运用生物信息学预测乳腺癌相关的外源性miRNA潜在靶点，旨在为miRNA在乳腺癌治疗中的应用提供参考。

    Abstract:

    Breast cancer is one of the three most common cancers with the highest mortality rate in the world and poses a serious threat to human health.MicroRNA （miRNA），as a small molecule of gene regulation，can mediate cellular target genes to regulate the occurrence and development of breast cancer.In this paper，we classified miRNA according to their sources，reviewed the currently known functional properties of endogenous and exogenous miRNA （botanmin），and explored their regulatory mechanisms in breast cancer.At the same time，the potential targets of exogenous miRNA associated with breast cancer were predicted by bioinformatics，which provided a reference for their application in breast cancer therapy.

    表 3 对乳腺癌具有潜在治疗作用的miRNATable 3 miRNAs with potential therapeutic effects on breast cancer
    图1 miRNA的调控过程Fig.1 The regulation of miRNAs
    图2 调控乳腺癌的关键miRNAFig.2 Key miRNAs in regulating breast cancer
    表 2 乳腺癌中主要异常表达的外源性miRNA及对应靶基因Table 2 Main abnormally expressed exogenous miRNAs in breast cancer and their target genes
    表 1 乳腺癌中主要异常表达的内源性miRNA及对应靶基因Table 1 Main abnormally expressed endogenous miRNAs in breast cancer and their target genes
    参考文献
    [1] SIEGEL R L,MILLER K D,FUCHS H E,et al.Cancer statistics,2022 [J].CA Cancer J Clin,2022,72(1): 7-33.
    [2] XIA C,DONG X,LI H,et al.Cancer statistics in China and United States,2022: profiles,trends,and determinants [J].Chin Med J (Engl),2022,135(5): 584-590.
    [3] CHEN L,HEIKKINEN L,WANG C,et al.Trends in the development of miRNA bioinformatics tools [J].Brief Bioinform,2019,20(5): 1836-1852.
    [4] LEE Y S,DUTTA A.MicroRNAs in cancer [J].Annu Rev Pathol,2009,4: 199-227.
    [5] HE B,ZHAO Z,CAI Q,et al.miRNA-based biomarkers,therapies,and resistance in cancer [J].Int J Biol Sci,2020,16(14): 2628-2647.
    [6] MCGUIRE A,BROWN J A,KERIN M J.Metastatic breast cancer: the potential of miRNA for diagnosis and treatment monitoring [J].Cancer Metastasis Rev,2015,34(1): 145-155.
    [7] SABIT H,CEVIK E,TOMBULOGLU H,et al.Triple negative breast cancer in the era of miRNA[J/OL].Crit Rev Oncol Hematol,2021,157: 103196[2023-09-28].https://doi.org/10.1016/j.critrevonc.2020.103196.
    [8] ZHOU Z,LI X,LIU J,et al.Honeysuckle-encoded atypical microRNA2911 directly targets influenza A viruses [J].Cell Res,2015,25(1): 39-49.
    [9] YI D D,XU L,WANG R,et al.miR-381 overcomes cisplatin resistance in breast cancer by targeting MDR1 [J].Cell biology international,2019,43(1): 12-21.
    [10] SENGUPTA D,DEB M,KAR S,et al.Dissecting miRNA facilitated physiology and function in human breast cancer for therapeutic intervention [J].Seminars in cancer biology,2021,72: 46-64.
    [11] TREIBER T,TREIBER N,MEISTER G.Regulation of microRNA biogenesis and its crosstalk with other cellular pathways [J].Nature reviews molecular cell biology,2019,20(1): 5-20.
    [12] MACFARLANE L-A,R.MURPHY P.MicroRNA: biogenesis,function and role in cancer [J].Current genomics,2010,11(7): 537-561.
    [13] 孙嘉玲,文彬,孙海涛,等．miRNAs与肝细胞癌的相关性研究进展[J]．中国药理学通报,2017,33(4):445-449．SUN J L,WEN B,SUN H T,et al．Research progress of relevance between miRNAs and hepatocellular carcinoma[J]．Chinese pharmacological bulletin,2017,33(4):445-449 (in Chinese with English abstract)．
    [14] HOU D,HE F,MA L,et al.The potential atheroprotective role of plant MIR156a as a repressor of monocyte recruitment on inflamed human endothelial cells [J].J Nutr Biochem,2018,57: 197-205.
    [15] 朱文卿,任汉书,郑媛媛,等．金银花的功能性成分及其生物活性研究进展[J]．食品工业科技,2021,42(13):412-426．ZHU W Q,REN H S,ZHENG Y Y,et al．Research progress in functional components and bioactivity of honeysuckle[J]．Science and technology of food industry,2021,42(13):412-426 (in Chinese with English abstract)．
    [16] 祝家笙,高维浩,范红艳．金银花提取物药理作用的研究进展[J]．吉林医药学院学报,2022,43(2):130-132．ZHU J S,GAO W H,FAN H Y．Research progress on pharmacological effects of honeysuckle extract[J]．Journal of Jilin Medical University,2022,43(2):130-132 (in Chinese with English abstract)．
    [17] LEE R C,FEINBAUM R L,AMBROS V.The C.elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 [J].Cell,1993,75(5): 843-854.
    [18] HILL M,TRAN N.miRNA interplay: mechanisms and consequences in cancer[J/OL].Dis Model Mech,2021,14(4): dmm047662[2023-09-28].https://doi.org/10.1242/dmm. 047662.
    [19] ZHANG L,HOU D,CHEN X,et al.Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA [J].Cell Res,2012,22(1): 107-126.
    [20] AKAO Y,KURANAGA Y,HEISHIMA K,et al.Plant hvu-MIR168-3p enhances expression of glucose transporter 1 (SLC2A1) in human cells by silencing genes related to mitochondrial electron transport chain complex I[J/OL].J Nutr Biochem,2022,101: 108922[2023-09-28].https://doi.org/10.1242/dmm.047662.
    [21] LANG C,KARUNAIRETNAM S,LO K R,et al.Common variants of the plant microRNA-168a exhibit differing silencing efficacy for human low-density lipoprotein receptor adaptor protein 1 (LDLRAP1) [J].Microrna,2019,8(2): 166-170.
    [22] KIM T M,YANG I S,SEUNG B J,et al.Cross-species oncogenic signatures of breast cancer in canine mammary tumors[J/OL].Nat Commun,2020,11(1): 3616[2023-09-28].https://doi.org/10.1038/s41467-020-17458-0.
    [23] 毛玉娣,丁西平,王华.微小RNA与胃癌关系的研究进展 [J].中国药理学通报,2016,32(6): 756-760.MAO Y D,DING X P,WANG H.Research progress on relationship between microRNA and gastric cancer[J].Chin Pharmacol Bull,2016,32(6): 756-760 (in Chinese with English abstract).
    [24] COSENTINO G,PLANTAMURA I,TAGLIABUE E,et al.Breast cancer drug resistance: overcoming the challenge by capitalizing on microRNA and tumor microenvironment interplay[J/OL].Cancers (Basel),2021,13(15): 3691[2023-09-28].https://doi.org/10.3390/cancers13153691.
    [25] WU T,SONG H,XIE D,et al.Mir-30b-5p promotes proliferation,migration,and invasion of breast cancer cells via targeting ASPP2[J/OL].Biomed Res Int,2020,2020: 7907269[2023-09-28].https://doi.org/10.1155/2020/7907269.
    [26] CHEN J,JIANG Q,JIANG X Q,et al.miR-146a promoted breast cancer proliferation and invasion by regulating NM23-H1 [J].J Biochem,2020,167(1): 41-48.
    [27] LU Y,HU X,YANG X.miR-934 promotes breast cancer metastasis by regulation of PTEN and epithelial-mesenchymal transition[J/OL].Tissue cell,2021,71: 101581[2023-09-28].https://doi.org/10.1016/j.tice.2021.101581.
    [28] LU C,ZHAO Y,WANG J,et al.Breast cancer cell-derived extracellular vesicles transfer miR-182-5p and promote breast carcinogenesis via the CMTM7/EGFR/AKT axis[J/OL].Mol Med,2021,27(1): 78[2023-09-28].https://doi.org/10.1186/s10020-021-00338-8.
    [29] YIN H,WANG Y,WU Y,et al.EZH2-mediated epigenetic silencing of miR-29/miR-30 targets LOXL4 and contributes to tumorigenesis,metastasis,and immune microenvironment remodeling in breast cancer[J].Theranostics,2020,10(19):8494-8512.
    [30] LIU D Z,CHANG B,LI X D,et al.MicroRNA-9 promotes the proliferation,migration,and invasion of breast cancer cells via down-regulating FOXO1 [J].Clinical & translational oncology,2017,19(9): 1133-1140.
    [31] MANSOORI B,DUIJF P H G,MOHAMMADI A,et al.MiR-142-3p targets HMGA2 and suppresses breast cancer malignancy[J/OL].Life Sci,2021,276: 119431[2023-09-28].https://doi.org/10.1016/j.lfs.2021.119431.
    [32] HU Y,QIU Y,YAGUE E,et al.miRNA-205 targets VEGFA and FGF2 and regulates resistance to chemotherapeutics in breast cancer[J/OL].Cell Death Dis,2016,7(6): e2291[2023-09-28].https://doi.org/10.1038/cddis.2016.194.
    [33] GAO X H,ZHANG Y L,ZHANG Z Y,et al.MicroRNA-96-5p represses breast cancer proliferation and invasion through Wnt/β-catenin signaling via targeting CTNND1[J/OL].Sci Rep,2020,10(1): 44[2023-09-28].https://doi.org/10.1038/s41598-019-56571-z.
    [34] HAGHI M,TAHA M F,JAVERI A.Suppressive effect of exogenous miR-16 and miR-34a on tumorigenesis of breast cancer cells [J].J Cell Biochem,2019,120(8): 13342-13353.
    [35] HOSEINBEYKI M,TAHA M F,JAVERI A.miR-16 enhances miR-302/367-induced reprogramming and tumor suppression in breast cancer cells [J].IUBMB life,2020,72(5): 1075-1086.
    [36] CHIN A R,FONG M Y,SOMLO G,et al.Cross-kingdom inhibition of breast cancer growth by plant miR159 [J].Cell Res,2016,26(2): 217-228.
    [37] 李孟,梁则徐,李冠男,等.中医中药治疗乳腺癌的研究进展 [J].中医药学报,2023,51(2): 103-108.LI M,LIANG Z X,LI G N,et al.Research progress in treatment of breast cancer with TCM [J].Acta Chinese medicine and pharmacology,2023,51(2): 103-108 (in Chinese with English abstract).
    [38] 袁泽焕,蔡煜佳.基于数据挖掘中医药治疗乳腺癌用药规律 [J].河南中医,2022,42(11): 1714-1719.YUAN Z H,CAI Y J.On the medication law of TCM in treating breast cancer based on data mining [J].Henan traditional Chinese medicine,2022,42(11): 1714-1719 (in Chinese with English abstract).
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雷志鑫,杨海旖,谢浩,环世娇,孙涛垒. miRNA在乳腺癌中的研究进展[J].华中农业大学学报,2024,43(5):149-156

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  • 收稿日期:2023-09-28
  • 在线发布日期: 2024-10-08
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