中国农业科学院油料作物研究所/农业农村部油料作物生物学与遗传育种重点实验室/农业农村部植物生态环境安全监督检验测试中心，武汉 430062
刘晓悦，E-mail：17860395910@139.com
刘芳，E-mail：liufang03@caas.cn
农业农村部转基因生物新品种培育重大专项（SQ2019ZD080018）；中国农业科学院油料作物研究所所级重点任务新兴学科建设合成生物学专项（CAAS-OCRI-XKPY-202106）刘晓悦，E-mail：17860395910@139.com
- LIU Xiaoyue
LIU Xiaoyue
Key Laboratory of Biology and Genetic Breeding of Oil Crops，Ministry of Agriculture and Rural Affairs/Oil Crops Research Institute，Chinese Academy of Agricultural Sciences/Plant Ecological Environment Safety Supervision and Testing Center，Ministry of Agriculture and Rural Affairs，Wuhan 430062，China
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WANG Pandi
Key Laboratory of Biology and Genetic Breeding of Oil Crops，Ministry of Agriculture and Rural Affairs/Oil Crops Research Institute，Chinese Academy of Agricultural Sciences/Plant Ecological Environment Safety Supervision and Testing Center，Ministry of Agriculture and Rural Affairs，Wuhan 430062，China
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XIONG Xiaojuan
Key Laboratory of Biology and Genetic Breeding of Oil Crops，Ministry of Agriculture and Rural Affairs/Oil Crops Research Institute，Chinese Academy of Agricultural Sciences/Plant Ecological Environment Safety Supervision and Testing Center，Ministry of Agriculture and Rural Affairs，Wuhan 430062，China
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WU Gang
Key Laboratory of Biology and Genetic Breeding of Oil Crops，Ministry of Agriculture and Rural Affairs/Oil Crops Research Institute，Chinese Academy of Agricultural Sciences/Plant Ecological Environment Safety Supervision and Testing Center，Ministry of Agriculture and Rural Affairs，Wuhan 430062，China
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LIU Fang
Key Laboratory of Biology and Genetic Breeding of Oil Crops，Ministry of Agriculture and Rural Affairs/Oil Crops Research Institute，Chinese Academy of Agricultural Sciences/Plant Ecological Environment Safety Supervision and Testing Center，Ministry of Agriculture and Rural Affairs，Wuhan 430062，China
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Key Laboratory of Biology and Genetic Breeding of Oil Crops，Ministry of Agriculture and Rural Affairs/Oil Crops Research Institute，Chinese Academy of Agricultural Sciences/Plant Ecological Environment Safety Supervision and Testing Center，Ministry of Agriculture and Rural Affairs，Wuhan 430062，China
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神经酸（NA）是一种超长链单不饱和脂肪酸，为大脑神经纤维髓鞘的核心成分，具有修复受损大脑神经纤维、促进神经细胞再生等功能。因此，NA受到越来越多的研究和关注。目前NA主要依赖于从天然物种中提取，难以满足市场需要，限制其进一步发展和应用。近年来，随着基因工程以及合成生物学的发展，通过多基因策略，在现有物种中构建NA代谢路径，可经济且可持续地获得NA，以满足营养、制药和化学工业等领域的需求。本文综述了NA的生物功能、生物来源、合成途径，并比较了基因工程生产NA各底盘的优劣，进一步探讨了十字花科油料作物底盘生产富含NA种子油的影响因素，以期为将来通过转基因技术和分子育种调控NA的生产，获得可再生的NA资源提供一定的思路和策略。
Neuronic acid （NA） is an ultra-long chain monounsaturated fatty acid，a core component of the myelin sheath of brain nerve fibers，with functions including repairing damaged brain nerve fibers and promoting regeneration of nerve cell.Therefore，more and more studies are focusing on NA.At present，NA mainly relies on extraction from natural species，which is difficult to meet market needs and limits its further development and application.In recent years，with the development of genetic engineering and synthetic biology，constructing NA metabolic pathways in existing species through multi-gene strategies can economically and sustainably obtain NA to meet the needs of fields such as nutrition，pharmaceuticals，and chemical industries.This article reviewed the biological functions，biological sources，and synthetic pathways of NA.The advantages and disadvantages of genetic engineering production of NA chassis were compared.The influencing factors of producing NA-rich seed oil using cruciferous oil crops as the chassis were further explored.It will provide some ideas and strategies for regulating NA production and obtaining renewable NA resources in the future through transgenic technology and molecular breeding.
引用本文
刘晓悦,王盼娣,熊小娟,吴刚,刘芳.油料作物种子中神经酸含量提升研究进展[J].华中农业大学学报,2024,43(2):64-74
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- 收稿日期:2023-10-10
- 在线发布日期: 2024-04-02
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