首页 > 过刊浏览>2023年第42卷第2期 >48-62. DOI:10.13300/j.cnki.hnlkxb.2023.02.007
PDF HTML阅读 XML下载 导出引用 引用提醒
我国牛群中牛病毒性腹泻病毒流行的Meta分析
CSTR:
[cstr]
作者:
作者单位:

1.华中农业大学动物医学院,武汉 430070;2.农业微生物资源发掘与利用全国重点实验室,武汉 430070;3.湖北洪山实验室,武汉 430070;4.湖北工业大学工业设计学院,武汉 430070

作者简介:

朱杰，E-mail： zhujie0128@webmail.hzau.edu.cn

通讯作者:

郭爱珍，E -mail：aizhen@mail.hzau.edu.cn

中图分类号:

S852.65+3

基金项目:

国家现代农业产业技术体系专项（CARS-37）


Meta analysis of prevalence of bovine viral diarrhea virus （BVDV） in cattle in China
Author:
Affiliation:

1.College of Veterinary Medicine,Huazhong Agricultural University,Wuhan 430070,China;2.State Key Laboratory of Agricultural Microbiology,Wuhan 430070,China;3.Hubei Hongshan Laboratory,Wuhan 430070,China;4.School of Industrial Design,Hubei University of Technology,Wuhan 430070,China

  • 摘要
    • |
  • 图/表
    • |
  • 访问统计
    • |
  • 参考文献 [24]
    • |
  • 相似文献 [20]
    • | | |
  • 文章评论
    摘要:

    为全面评估我国牛群中牛病毒性腹泻病毒（bovine viral diarrhea virus，BVDV）病原流行率对该病毒感染的防控，在中国知网（CNKI）、万方、维普、PubMed和ScienceDirect 5个数据库中，检索截止到2021年9月1日发表的关于中国牛群BVDV流行情况的文献，并进行系统评价和Meta分析。共筛选出93篇关于BVDV病原学检测的研究论文纳入Meta分析中。分析结果显示：我国牛群中BVDV病原（抗原和核酸）流行率为9.8%（95%CI：7.8，11.9），其中BVDV抗原流行率为3.1%（95%CI：2.1，4.4），BVDV核酸流行率为19.5%（95%CI：16.0，23.3）。各省间比较发现，吉林流行率最高，为26.3% （95%CI：24.3，28.4），其次是湖北和福建省。进一步开展亚组分析和Meta回归分析的结果显示，品种（牦牛vs奶牛：比值比（odds ratio，OR）=1.37，95%CI：1.05~1.79）、饲养模式（散养vs规模化：OR=1.41，95%CI：1.08~1.85）、诊断方法（RT-PCR vs ELISA：OR=1.64，95%CI：1.38~1.94）、牛体健康状况（有临床症状vs无临床症状：OR=1.42，95%CI：1.20~1.68）、高山高原气候（OR=1.54，95%CI：1.20~1.97）和高海拔（>3 000 m；OR=1.64，95%CI：1.21~2.21）等都是BVDV感染流行的风险因子。以上结果表明，BVDV在我国奶牛、肉牛和牦牛群体中广泛流行，有必要持续监测BVDV感染的流行情况。此外，可根据本研究揭示的风险因子，制定相应的防控方案，防止 BVDV 在我国牛群中传播。

    Abstract:

    Bovine viral diarrhea virus （BVDV） is one of the most important pathogens in cattle diseases，causing serious economic losses to the cattle industry worldwide. A comprehensive assessment of the prevalence of BVDV in cattle herds in China is of great significance for the prevention and control of BVDV infection. We conducted a systematic review and Meta-analysis on the BVDV detection rate in cattle in China by searching the literatures published from 1981 to September 1，2021 on China National Knowledge Infrastructure （CNKI），Wanfang Database，VIP Chinese Journals Database，PubMed and ScienceDirect. A total of 93 studies on BVDV pathogenic detection were selected and included in this Meta-analysis. The overall prevalence rate of BVDV in cattle herds in China was estimated to be 9.8% （95%CI：7.8-11.9），among which the prevalence rate of BVDV antigen was 3.1% （95%CI：2.1-4.4），and the prevalence rate of BVDV nucleic acid was 19.5% （95%CI：7.5-23.3）. In the subgroup of sampled province，Jilin Province had the highest combined prevalence rate （26.3%，95%CI：24.3-28.4），followed by Hubei Province （24.6%） and Fujian Province （22.4%）. Subgroup analysis and Meta regression analysis showed that breed （yak vs dairy cattle； OR=1.37，95%CI：1.05-1.79），breeding mode （free-ranging vs large-scale；OR=1.41，95%CI： 1.08-1.85），diagnosis method （RT-PCR vs ELISA； OR=1.64，95%CI： 1.38-1.94），and animal health （clinical symptoms vs asymptomatic； OR=1.42，95%CI： 1.20-1.68） were the factors that significantly increased the prevalence rate of BVDV. In addition，plateau alpine （OR=1.54，95%CI： 1.20-1.97） and high altitude （>3 000 m； OR=1.64，95%CI： 1.21-2.21） geographical and climatic factors may promote the prevalence of BVDV. The above results show that BVDV is widely prevalent in dairy cattle，beef cattle，and yak populations in China. Therefore，it is necessary to continuously monitor the prevalence of BVDV infection. In addition，according to the risk factors identified in this study，the corresponding prevention and control programs should be made to prevent the spread of BVDV in cattle herds in China.

    表 3 我国牛群BVDV病原学流行率的分布Table 3 Spatial distribution of BVDV prevalence in cattle in China
    表 5 我国牛群中BVDV感染的地理和气候因素Table 5 Geographical and climatic factors of BVDV infection in cattle in China
    表 4 我国在不同牛种中的BVDV病原流行率及其风险因子相关性分析Table 4 Pooled prevalence of BVDV in different cattle breeds in China and their correlation analysis on risk factors
    表 2 Table 2
    表 1 纳入本研究的文献及其相关信息Table 1 Literatures and information included in this study
    图2 发表文献偏倚和剪补法校正Fig.2 Publication bias of the literatures and the correction with filled funnel plot
    图3 不同地区牛群中BVDV抗原流行率和核酸流行率间的比较Fig.3 The antigen and nucleic acid prevalence of BVDV in cattle from different regions
    参考文献
    [1] PINIOR B,FIRTH C L,RICHTER V,et al. A systematic review of financial and economic assessments of bovine viral diarrhea virus (BVDV) prevention and mitigation activities worldwide [J]. Prev Vet Med,2017,137(Pt A): 77-92.
    [2] DENG M,CHEN N,GUIDARINI C,et al. Prevalence and genetic diversity of bovine viral diarrhea virus in dairy herds of China [J/OL]. Vet Microbiol,2020,242: 108565 [2022-01-06]. https://doi.org/10.1016/j.vetmic.2019.108565.
    [3] CHANG L,QI Y,LIU D,et al. Molecular detection and genotyping of bovine viral diarrhea virus in Western China [J/OL]. BMC Vet Res,2021,17(1): 66[2022-01-06]. https://doi.org/10.1186/s12917-021-02747-7.
    [4] BAKER J C. The clinical manifestations of bovine viral diarrhea infection [J]. Vet Clin North Am Food Anim Pract,1995,11(3): 425-445.
    [5] LANYON S R,HILL F I,REICHEL M P,et al. Bovine viral diarrhoea: pathogenesis and diagnosis [J]. Vet J,2014,199(2): 201-209.
    [6] DUBOVI E J. Laboratory diagnosis of bovine viral diarrhea virus [J]. Biologicals,2013,41(1): 8-13.
    [7] RAN X,CHEN X,MA L,et al. A systematic review and meta-analysis of the epidemiology of bovine viral diarrhea virus (BVDV) infection in dairy cattle in China [J]. Acta Trop,2019,190: 296-303.
    [8] DIAO N C,GONG Q L,LI J M,et al. Prevalence of bovine viral diarrhea virus (BVDV) in yaks between 1987 and 2019 in mainland China: a systematic review and meta-analysis [J/OL]. Microb Pathog,2020,144: 104185 [2022-01-06]. https://doi.org/10.1016/j.micpath.2020.104185.
    [9] SMIRNOVA N P,WEBB B T,MCGILL J L,et al. Induction of interferon-gamma and downstream pathways during establishment of fetal persistent infection with bovine viral diarrhea virus [J]. Virus Res,2014,183: 95-106.
    [10] PETERHANS E,SCHWEIZER M. BVDV: a pestivirus inducing tolerance of the innate immune response [J]. Biologicals,2013,41(1): 39-51.
    [11] HANON J B,VAN DER STEDE Y,ANTONISSEN A,et al. Distinction between persistent and transient infection in a bovine viral diarrhoea (BVD) control programme: appropriate interpretation of real-time RT-PCR and antigen-ELISA test results [J]. Transbound Emerg Dis,2014,61(2): 156-62.
    [12] RAUE R,HARMEYER S S,NANJIANI I A. Antibody responses to inactivated vaccines and natural infection in cattle using bovine viral diarrhoea virus ELISA kits: assessment of potential to differentiate infected and vaccinated animals [J]. Vet J,2011,187(3): 330-334.
    [13] TUNCER P,YE?ILBA? K. Serological detection of infection dynamics for respiratory viruses among dairy calves [J]. Vet Microbiol,2015,180(3/4): 180-185.
    [14] BARENDREGT J J,DOI S A,LEE Y Y,et al. Meta-analysis of prevalence [J]. Journal of epidemiology and community health,2013,67(11): 974-978.
    [15] FULTON R W,PURDY C W,CONFER A W,et al. Bovine viral diarrhea viral infections in feeder calves with respiratory disease: interactions with Pasteurella spp.,parainfluenza-3 virus,and bovine respiratory syncytial virus [J]. Can J Vet Res,2000,64(3): 151-159.
    [16] SCHARNBOCK B,ROCH F F,RICHTER V,et al. A meta-analysis of bovine viral diarrhoea virus (BVDV) prevalences in the global cattle population [J/OL]. Sci Rep,2018,8(1): 14420[2022-01-06]. https://doi.org/10.1038/s41598-018-32831-2.
    [17] SMITH R L,SANDERSON M W,JONES R,et al. Economic risk analysis model for bovine viral diarrhea virus biosecurity in cow-calf herds [J]. Prev Vet Med,2014,113(4): 492-503.
    [18] QIU Q,ZHANG G,MA T,et al. The yak genome and adaptation to life at high altitude [J]. Nature genetics,2012,44(8): 946-949.
    [19] 翟岁显,孙爱存. 论海拔与经济的关系:兼论“海拔效应”对青藏高原地区经济开发的启示 [J]. 青海民族研究,2012,23(2): 152-159. ZHAI S X,SUN A C．On the relationship between altitude and economy:the inspiration of altitude effects to the economic development of the Qinghai-Tibet Plateau region[J]．Nationalities research in Qinghai,2012,23(2):152-159(in Chinese with English abstract)．
    [20] SALIKI J T,DUBOVI E J. Laboratory diagnosis of bovine viral diarrhea virus infections [J]. Vet Clin North Am Food Anim Pract,2004,20(1): 69-83.
    [21] GONG Q L,WANG Q,YANG X Y,et al. Seroprevalence and risk factors of the bluetongue virus in cattle in China from 1988 to 2019: a comprehensive literature review and meta-analysis [J/OL]. Front Vet Sci,2020,7: 550381 [2022-01-06]. https://doi.org/10.3389/fvets.2020.550381.
    [22] AL-KUBATI A A G,HUSSEN J,KANDEEL M,et al. Recent advances on the bovine viral diarrhea virus molecular pathogenesis,immune response,and vaccines development [J/OL]. Front Vet Sci,2021,8: 665128 [2022-01-06].https://doi.org/10.3389/fvets.2021.665128.
    [23] SMITH D B,MEYERS G,BUKH J,et al. Proposed revision to the taxonomy of the genus pestivirus,family Flaviviridae [J]. J Gen Virol,2017,98(8): 2106-2112.
    [24] PASSLER T,WALZ P H. Bovine viral diarrhea virus infections in heterologous species [J]. Anim Health Res Rev,2010,11(2): 191-205.
    引证文献
    网友评论
    网友评论
    分享到微博
    发 布
引用本文

朱杰,杨才俊,祁明普,杨凯辉,王宇,陈颖钰,陈曦,胡长敏,郭爱珍.我国牛群中牛病毒性腹泻病毒流行的Meta分析[J].华中农业大学学报,2023,42(2):48-62

复制
分享
文章指标
  • 点击次数:783
  • 下载次数: 2037
  • HTML阅读次数: 416
  • 引用次数: 0
历史
  • 收稿日期:2022-01-06
  • 在线发布日期: 2023-03-31
文章二维码

联系我们

电话： 027-87287437，027-87287364
邮政编码： 430070
E-mail：hnlkxb@mail.hzau.edu.cn
地址： 武汉市洪山区狮子山街1号

期刊订阅 Email Alert 国际标准刊号：ISSN 1000-2421 国外邮发代号：BM 3816 国内刊号：CN 42-1181/S 国内发行代号：38-120

华中农业大学学报（自然科学版） ® 2025 版权所有   技术支持：北京勤云科技发展有限公司