In order to evaluate the application effectiveness of integrated soil-crop system management （ISSM） and provide technical support for sustainable high yield and efficiency in regional crop production， based on the long-term （2009－2020） located experiment we discussed the effects of no fertilization（CK），farmer’s practice（FP），high yield management（HY）and ISSM on maize yield，plant phosphorus （P）and potassium （K） uptake，use efficiency and soil P and K nutrient status. The results showed that the grain yield in CK treatment decreased dramatically during the 12-year experimental period，a slightly decreased yield trend was found in FP treatment，while continually increased yields trends were observed in HY and ISSM treatments. Compared with FP treatment，ISSM treatment significantly increased the average yield and plant P and K uptake by 26%，24% and 32%，respectively，and reached 98%，91% and 85% of those in HY treatment. The average use efficiency of P and K fertilizer in ISSM treatment were 18.7，1.2 units higherthan those in FP treatment，and 17.4，24.8 units higher than those in HY treatment，respectively. Compared with FP treatment，the 12-year adopting ISSM significantly increased total and available contents of P and K in 0-20 and 20-40 cm soil layers，and available contents of P and K for all the aggregate size fractions in 0-20 cm soil layer. The positive and significant correlations were observed between all the measured parameters，of which the stronger correlations were found among grain yield，plant P and K uptake and use efficiency，as well as between soil P and K contents and those in the aggregate fractions that > 0.25 mm size. In conclusion，ISSM could achieve long-term high and stable yield for spring maize，increase P and K uptake and utilization in plants，and improve soil P and K nutrient supply capacity，consequently promote the sustainable development in the whole soil-crop system.