Huanglongbing (HLB) is one of the most devastating disease of citrus worldwide,which has caused huge economic losses.It is caused by phloem limited bacteria Candidatus liberibacters ,and disseminated in orchards by Diaphorina citri (Kuwayama) .At present,the main prevention methods of HLB disease are as follows:first,the traditional “three axes” prevention and controlling strategy,namely,planting pathogen free citrus,removing the infected plants,and large scale successive killing of psylla; second,drug control,mainly including antibiotic drugs，narrow E44spectrum targeted drugs，immune inducers，nano agents and other antibacterial agents.This review systematically discusses the development on drug control of citrus HLB at home and abroad,hoping to provide theoretical basis and reference for the research and development of new drug for citrus HLB.