Tongcheng pig is the first batch of breeds to be listed on the national protection list of livestock and poultry breeds. It is a representative breed of “Huazhong Two-End-Black pig” and the meat of it tastes delicious,tender and succulent. At the same time,it is found that Tongcheng pig has special resistance to High pathogenic Porcine Reproductive and Respiratory Syndrome virus. In order to retain the advantages of disease resistance and meat quality,and improve the deficiency of slow growth and low lean ratio of Tongcheng pigs,Etong Two-End-Black was cross bred by introducing lean meat varieties. To compare the differences between Etong Two-End-Black and Tongcheng pig in nutrition and flavor compounds,amino acids,fatty acids,inosine acids and thiamine in the longissimus dorsi muscle of 30 Etong Two-End-Black and 29 Tongcheng pig were measured. The results showed that there were various kinds of amino acids in the Tongcheng pig muscle,the total content of 16 kinds of amino acids was (19.42±1.31) g/100 g,the content of essential amino acid (EAA) was (8.47±0.98) g/100 g,and the content of fresh amino acid (FAA) was (6.80±0.46) g/100 g. Tongcheng pig was rich in fatty acids and had high nutritional flavor value,the content of saturated fatty acid was 43.04%±1.84%,the content of unsaturated fatty acid was 56.96%±1.84%,in which the content of monounsaturated fatty acid (MUFA) was 47.47%±2.63% and the content of polyunsaturated fatty acid (PUFA) was 9.50%±2.50%,and the content of linoleic acid was 8.93%±2.36%. The content of flavor compounds,thiamine was 0.23±0.05 mg/100 g and inosinic acid was (3.23±0.67) mg/g,which were the material basis of Tongcheng meat quality and taste. The content of PUFA (12.08%±4.72%),linoleic acid (11.36%±4.44%) and thiamine ((0.23±0.05) mg/100 g) in Etong Two-End-Black were significantly or extremely significantly higher than those of Tongcheng,and the above other traits were not significantly different from Tongcheng pigs (P＞0.05). The above results showed that the pork of the two breeds had the characteristics of high nutritional value and unique flavor,Etong Two-End-Black pig not only retain the nutritional and flavor of Tongcheng pig,but had higher contents of PUFA and thiamine,which is worthy of further development and utilization.