To explore the association between diarrhea of Large White piglets and polymorphism of CL10 and Nrampl1 gene, a population of 490 Large White piglets before weaning was established and PCR-RFLP was carried out to examine the polymorphism of 3′ 1149T/C locus of BCL10 gene and the NdeⅠ restriction site in the 6th intron of Nramp1 gene. Subsequently, correlation analysis of gene polymorphism with diarrhea rate (DR), diarrhea index (DI) and several growth characteristics were performed. The results showed that DR of Large White piglets before weaning was 32.0%, average weaning weight and average daily gain of severe diarrhea individuals decreased by 13.0% and 16.2%, respectively. According to the results, piglets were easy to get diarrhea during two periods (711 and 1721 days of age). Pathogen was detected from diarrhea piglets and 22.5% of them were caused by salmonella and 17.5% by enteropathogenic Escherichia coli (EPEC). The polymorphism of BCL10 gene was extremely significantly correlated with BW (P<0.01). Specifically, DR and DI of individuals with different genotypes were TT>TC>CC, with difference between CC and TC was significant (P<0.05) and between CC and TT was extremely significant (P<0.01). The polymorphism of NdeⅠ restriction sites in the 6th intron of Nramp1 gene was extremely significantly correlated with DR and DI (P<0.01) . The DR and DI level of piglets with AA and AB genotypes were much higher than that of BB genotype. The difference between AA and BB genotypes was significant (P<0.05), and between AB and BB genotypes was extremely significant (P<0.01). In summary, the result illustrated that polymorphism of BCL10 and Nramp1 gene was significantly related to diarrhea degree in Large White piglets, and the 3′ 1149T/C locus of BCL10 gene and the SNP of the NdeⅠ restriction site in the 6th intron of Nramp1 gene could be used as molecular markers for genetic selection in pig breeding.