One hundred and twelve Streptococcus suis and 92 Haemophilus parasuis were isolated from pig farm to investigate susceptibility of the two bacteria strains to 23 antimicrobials by using disk diffusion method.Results showed that for the S.suis strain，the resistance rates of lincosamide，macrolides and nitrofurans were all above 90%，followed by streptomycin，gentamicin，kanamycin，amikacin and doxycycline with the resistance rates ranged from 60% to 90% and resistance rates of β-lactams and quinolones were relatively lower.For the H.parasuis strain，the resistance rate of tetracycline was the highest (78.3%)，followed by spiramycin，sulfamethoxazole/TMP，clindymycin，lincomycin，amikacin and neomycin varied from 50% to 70% and resistance rates of cephalosporins and quinolones were relatively lower.The susceptibility of the two kinds of bacteria to the antimicrobials were different，multiple resistance was severe and the resistance profiles were various.