For a long time, whether eating persimmons can lead to gastric bezoars was controversial. The public's concerns about eating persimmons have severely restricted the development of persimmon industry. However, until now, no systematic studies have confirmed that eating persimmons can cause bezoars. Therefore, this study aimed to evaluate whether daily consumption of persimmon fruits could cause gastric bezoars. In stimulated gastric fluid system, we confirmed that the flocculation ability of tannins with food ingredients cannot been considered for its bezoars formation risk. In the animal system, our results showed that no bezoars were found in the stomach, and no intracorporal pathogenic properties were observed according to the hematological and stomach parameters after 30 days’ continuous intake of persimmon. Additionally, both volunteer tests and questionnaires in typical persimmon growing region revealed that consuming two persimmon fruits (400-500 g) daily for healthy person did not lead to gastric bezoars. Altogether, this study preliminarily confirmed that healthy adults eating two persimmons daily did not cause gastric bezoars.