Cassava common mosaic virus （CsCMV） is the primary agent causing cassava mosaic disease.Its capsid protein （CP） plays a crucial role in virus-plant interactions during infection.Glutaredoxins （GRXs） are thiol oxidoreductases with low molecular weight， among which CC-type GRXs are key regulators of resistance to plant disease.Given that CP is a key pathogenicity factor of CsCMV involved in modulating host immune responses， this article investigated whether CsCP interacts with MeGRXC3 to synergistically regulate redox homeostasis and thereby modulate viral infection.The yeast two-hybrid （Y2H）， bimolecular fluorescence complementation （BiFC）， and subcellular localization assays were used to examine the interaction between CsCP and MeGRXC3.The results showed that there was an interaction between cassava MeGRXC3 and CsCP in yeast cells.Green fluorescence appeared at 488 nm after co-expressing MeGRXC3 and CsCP in Nicotiana benthamiana epidermal cells， confirming the interaction between CsCP and MeGRXC3 in plant cells.CsCP and MeGRXC3 exhibited co-localization in Nicotiana benthamiana epidermal cells.It is indicated that there is an interaction between CsCP and MeGRXC3.It will lay the groundwork for further elucidating the molecular mechanisms by which CP facilitates the infection of CsCMV.