The indicators for discriminating low-temperature and persistent rain at different growth stages of flue-cured tobacco were established to better defense against the adverse effects of low temperature and persistent rain disasters on the yield and quality of flue-cured tobacco in Hubei Province. The data of daily meteorology from 32 national meteorological observation stations in the tobacco planting areas of Hubei Province from 1975 to 2020 were used to in depth analyze the spatiotemporal distribution characteristics of seven disaster indicators related to the low temperature and persistent rain in the tobacco planting areas of Hubei Province. The results showed that three indicators including the average temperature during the process， the average daily precipitation， and the average total precipitation all followed an evolutionary pattern of low-high-low in terms of time， with the highest at the early stage of maturity and the lowest at the stage of root extension. The average number of days in the process was about 5 days. The average annual number of processes， the average annual days of process， and the frequency of disasters were the highest at the late stage of maturity and the lowest at the stage of vigorous growth. Among them， the frequency of disasters occurred 6 and 1 times every 10 years at these two stages， with a difference of nearly 6 times. In terms of space， there were consistent differences in temperature and precipitation between the north and south at different stages of growth. The tobacco growing areas in the northern had lower temperatures， while the tobacco growing areas in the southern had more precipitation with higher intensity. The average days of the process in the southern part was longer than that in the northern part at the stage of root extension and vigorous growth， while the opposite was true at the late stage of maturity. There was a significant spatial difference in the frequency of disasters. The frequency of disasters at the first three stage of growth in tobacco growing areas in the southern was higher than that in tobacco growing areas in the northern. The frequency of disasters at the late stage of maturity was equivalent to that in tobacco growing areas in the north and south， with an average duration of over 56% and an average duration of 5.7 days. It will provide a scientific basis for the planning of tobacco cultivation in Hubei and the defense against disasters of low-temperature and persistent rain.