我国牛群中牛病毒性腹泻病毒流行的Meta分析
作者:
作者单位:

1.华中农业大学动物医学院,武汉 430070;2.农业微生物资源发掘与利用全国重点实验室,武汉 430070;3.湖北洪山实验室,武汉 430070;4.湖北工业大学工业设计学院,武汉 430070

作者简介:

朱杰,E-mail: zhujie0128@webmail.hzau.edu.cn

通讯作者:

郭爱珍,E -mail:aizhen@mail.hzau.edu.cn

中图分类号:

S852.65+3

基金项目:

国家现代农业产业技术体系专项(CARS-37)


Meta analysis of prevalence of bovine viral diarrhea virus (BVDV) in cattle in China
Author:
Affiliation:

1.College of Veterinary Medicine,Huazhong Agricultural University,Wuhan 430070,China;2.State Key Laboratory of Agricultural Microbiology,Wuhan 430070,China;3.Hubei Hongshan Laboratory,Wuhan 430070,China;4.School of Industrial Design,Hubei University of Technology,Wuhan 430070,China

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    摘要:

    为全面评估我国牛群中牛病毒性腹泻病毒(bovine viral diarrhea virus,BVDV)病原流行率对该病毒感染的防控,在中国知网(CNKI)、万方、维普、PubMed和ScienceDirect 5个数据库中,检索截止到2021年9月1日发表的关于中国牛群BVDV流行情况的文献,并进行系统评价和Meta分析。共筛选出93篇关于BVDV病原学检测的研究论文纳入Meta分析中。分析结果显示:我国牛群中BVDV病原(抗原和核酸)流行率为9.8%(95%CI:7.8,11.9),其中BVDV抗原流行率为3.1%(95%CI:2.1,4.4),BVDV核酸流行率为19.5%(95%CI:16.0,23.3)。各省间比较发现,吉林流行率最高,为26.3% (95%CI:24.3,28.4),其次是湖北和福建省。进一步开展亚组分析和Meta回归分析的结果显示,品种(牦牛vs奶牛:比值比(odds ratio,OR)=1.37,95%CI:1.05~1.79)、饲养模式(散养vs规模化:OR=1.41,95%CI:1.08~1.85)、诊断方法(RT-PCR vs ELISA:OR=1.64,95%CI:1.38~1.94)、牛体健康状况(有临床症状vs无临床症状:OR=1.42,95%CI:1.20~1.68)、高山高原气候(OR=1.54,95%CI:1.20~1.97)和高海拔(>3 000 m;OR=1.64,95%CI:1.21~2.21)等都是BVDV感染流行的风险因子。以上结果表明,BVDV在我国奶牛、肉牛和牦牛群体中广泛流行,有必要持续监测BVDV感染的流行情况。此外,可根据本研究揭示的风险因子,制定相应的防控方案,防止 BVDV 在我国牛群中传播。

    Abstract:

    Bovine viral diarrhea virus (BVDV) is one of the most important pathogens in cattle diseases,causing serious economic losses to the cattle industry worldwide. A comprehensive assessment of the prevalence of BVDV in cattle herds in China is of great significance for the prevention and control of BVDV infection. We conducted a systematic review and Meta-analysis on the BVDV detection rate in cattle in China by searching the literatures published from 1981 to September 1,2021 on China National Knowledge Infrastructure (CNKI),Wanfang Database,VIP Chinese Journals Database,PubMed and ScienceDirect. A total of 93 studies on BVDV pathogenic detection were selected and included in this Meta-analysis. The overall prevalence rate of BVDV in cattle herds in China was estimated to be 9.8% (95%CI:7.8-11.9),among which the prevalence rate of BVDV antigen was 3.1% (95%CI:2.1-4.4),and the prevalence rate of BVDV nucleic acid was 19.5% (95%CI:7.5-23.3). In the subgroup of sampled province,Jilin Province had the highest combined prevalence rate (26.3%,95%CI:24.3-28.4),followed by Hubei Province (24.6%) and Fujian Province (22.4%). Subgroup analysis and Meta regression analysis showed that breed (yak vs dairy cattle; OR=1.37,95%CI:1.05-1.79),breeding mode (free-ranging vs large-scale;OR=1.41,95%CI: 1.08-1.85),diagnosis method (RT-PCR vs ELISA; OR=1.64,95%CI: 1.38-1.94),and animal health (clinical symptoms vs asymptomatic; OR=1.42,95%CI: 1.20-1.68) were the factors that significantly increased the prevalence rate of BVDV. In addition,plateau alpine (OR=1.54,95%CI: 1.20-1.97) and high altitude (>3 000 m; OR=1.64,95%CI: 1.21-2.21) geographical and climatic factors may promote the prevalence of BVDV. The above results show that BVDV is widely prevalent in dairy cattle,beef cattle,and yak populations in China. Therefore,it is necessary to continuously monitor the prevalence of BVDV infection. In addition,according to the risk factors identified in this study,the corresponding prevention and control programs should be made to prevent the spread of BVDV in cattle herds in China.

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朱杰,杨才俊,祁明普,杨凯辉,王宇,陈颖钰,陈曦,胡长敏,郭爱珍.我国牛群中牛病毒性腹泻病毒流行的Meta分析[J].华中农业大学学报,2023,42(2):48-62

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  • 收稿日期:2022-01-06
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  • 在线发布日期: 2023-03-31
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