For a long time,whether eating persimmons can lead to gastric bezoars is controversial. The public’s concerns about eating persimmons have severely restricted the development of persimmon industry. However,until now,no systematic studies have confirmed that eating persimmons can cause bezoars. Therefore,this study aimed to evaluate whether daily consumption of persimmon fruits can cause gastric bezoars. The turbidity analysis,centrifugal method and transmission electron microscope were used to study the flocculation of persimmon tannins and food components in a simulated gastric environment. Risks of “gastric persimmon bezoars” formation after consuming persimmon fruit were evaluated in the animal system through gastric anatomy observation,gastric function and histological examination. In stimulated gastric fluid system,we confirmed that the flocculation ability of tannins with food ingredients can’t be considered for the risk of bezoars formation. Results in the animal system showed that no bezoars were found in the stomach,and no intracorporal pathogenic properties were observed according to the hematological and stomach parameters after 30 days’ continuous intake of persimmon. Both volunteer tests and questionnaires in typical persimmon growing region revealed that consuming two persimmon fruits (400-500 g) daily for healthy person did not lead to gastric bezoars. It is preliminarily confirmed that eating two persimmons daily didn’t cause gastric bezoars for healthy adults.