Based on literature research,this paper clearly defines the connotation of “Technical Ontology” and then discusses the origin of technology alienation in accordance with large number of cases on technology negative effects and alienation phenomenon with the help of grounded theory.Through open coding,axial coding and selecting coding,this paper proposes the “two-dimension and three-point” concept model.From three aspects - technology ontology,motivation alienation and ability alienation,this paper explains the formation mechanism of technology negative effects,which both has a certain universal applicability and theoretical value and helps forecast negative effects of new technology.