Based on the investigation data of six provinces（Hubei,Anhui,Shandong,Zhejiang,Jiangsu,Hebei）,this paper uses Binary Logistic regression model to analyze the willingness and influencing factors of waterfowl farmers’ using safe drug additives.The result shows that participation in cultivation training or not,breeding methods,a place adjacent to lake or river,breeding years and the number of family members have a positive impact on the willingness of the farmers,while the number of labor and situation that farmers participated in the economic organizations have a negative impact on the willingness of the farmers.Therefore，this paper puts forward the following proposals on how to strengthen the training of breeding farmers,strengthen the cultivation of new agricultural business entities,actively develop and promote the healthy cultivation mode and strengthen the consolidation and support of the waterfowl industry.